Research Associate Formulation (senior)

06/08/21

Location

Galileilaan 19, Niel, Belgium

Function type

(Senior) Researsch Associate

Vacancy

General job description

The (senior) RA mRNA formulation is a hands-on person responsible for the formulation of mRNA into lipid-based nanoparticles and polymeric nanoparticles, the physicochemical characterization of these mRNA formulation and their in vitro assessment using cellular assays.  This position provides also input on the implementation, optimisation and validation of new methods to characterize mRNA formulations

 

This position reports into the senior scientist formulation and will be based in Ghent.

Responsibilities and Duties

The Research Associate mRNA formulation shall include, but not be limited to:

Core tasks:

  • Generation of lipid-based nanoparticles

  • Performing physico-chemical characterization including determination of pKa, zeta-potential, mRNA encapsulation efficiency and size determination

  • Assessment of mRNA integrity

  • Performing and analyzing in vitro cellular assays (transfection efficiency, innate activation, viability, cytokine release) using flow cytometry, ELISA, multiplex bead assays…

  • Executing general lab management tasks (managing lipid stocks, tissue culture facility…)

 Optional:

  • Assistance in the execution and analysis of basic in vivo experiments (bioluminescence imaging, blood sampling, …)

Job requirements

Education:

Professional Bachelor in Biomedical Laboratory Techniques or Master in Biomedical Sciences/Biotechnology/Pharmaceutical Sciences or related field or equivalent relevant laboratory experience

Experience:

  • Minimum of two years of relevant laboratory experience (can be both academic or industrial)

  • Experience in cellular assays

  • Broad knowledge of molecular biotechnology techniques (DNA/RNA isolation, RT-QPCR, Western Blot, ELISA)

  • Experience in flow cytometry is considered a plus

  • Prior experience in animal handling (FELASA B certificate) is considered a plus

  • Prior experience in formulation of polymer and/or lipid-based nanoparticle delivery systems is considered a plus

Other qualifications, skills and abilities:

  • Detail-oriented and accurate in following instructions, record keeping and completion of reports

  • Able to perform experimental troubleshooting and to propose technical solutions

  • Scientific integrity

  • Proficient in written and spoken English

  • Good communication skills

  • Well organized, well-structured, hands-on, result focused

  • Able to work under stringent time lines

  • Ability to foster teamwork and a collaborative atmosphere

  • Enthusiastic, flexible and able to multitask

  • Understanding of MS Office (Excel, Word, PowerPoint, Outlook)

Our offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development

  • Employment contract of unlimited duration with a competitive salary package with a lot of extra benefits

  • Work within a dynamic and fast-growing group with great colleagues

Job application