Senior/Principal Scientist in vitro biology



Gaston Geenslaan 1, Leuven, Belgium

Function type

Senior/Principal Scientist in vitro biology


Aelin Therapeutics is a biopharmaceutical company pioneering peptide-based novel drug modalities to create powerful first-in-class antibiotics and agents against high-value undruggable human targets. The technology, branded Pept-ins™, harnesses the power of protein aggregation to induce specific functional knockdown of a target protein. The Pept-in™ technology allows for the rational design of novel peptide-based therapeutics and differentiates itself from other therapeutic modalities through its unique mode of action, its designability and broad target space.

Aelin Therapeutics is building a motivated and innovative team to realize the therapeutic potential of Pept-ins. The company has activities in Ghent and Leuven, Belgium. This job opportunity is a vacancy at our Headquarters in Leuven.

For more information please visit


Reporting to Head of Biology, the ideal candidate will have a PhD degree in life sciences, with extensive experience in driving drug discovery projects in oncology. Additional skills in cell-based assay, biochemistry and biotechnology are essential. Knowledge in molecular biology is an advantage.   Experience in working as a researcher in biotechnology and/or drug discovery in the biopharmaceutical industry is mandatory.


  • Translate scientific ideas and questions into experimental valuable data by setting up and utilizing appropriate cell-based and biochemistry assays and readouts;

  • Design and implement mechanism of action studies that can be utilized for novel therapeutics in discovery, lead optimization, and preclinical development

  • Support and lead  research projects, maintain focus and provide guidance to the team members

  • Ensure a high-level scientific standard is maintained on all projects by ensuring quality controls, SOP, ELN’s, etc.

  • Leading a team, develop and organize activities of the in vitro biology; maintain focus and provide direction to the team members

  • Present complex scientific data in a clear, comprehensive manner. Collaborate and communicate with different stakeholders, both internally and externally

  • Establish and maintain a network in the academic world; manage academic collaborations; engage with KOLs

  • Involved in new target selection (oncology)

  • Involved in grant writing

  • Involved in IP filing strategy

Key skills

  • PhD (or equivalent) with at least 10 years of experience (including experience in biotech), with relevant work experience in drug discovery and development through cell biology, cellular pharmacology, translational medicine or related discipline

  • In-depth knowledge in the oncology therapeutic area is a requirement

  • Solid knowledge of drug discovery and development processes

  • Experience with proven track record in cellular target and disease-related in vitro assay development and target-based cellular assays that probe the pharmacological modulation of the target activity in the cellular context – any experience with peptides would be a plus.

  • Good understanding on how targets/ pathways can be modulated is a plus as well as knowledge in molecular cloning methodologies

  • Critical mindset when looking at scientific data, both from internal and external sources

  • Ability to drive multiple projects within a matrix-based organization and via external collaborations

  • Ability to adapt activities & priorities to meet challenging deliverables

Our offer

  • A competitive salary and benefits package

  • An entrepreneurial and stimulating working environment in an ambitious start-up biotech company

  • Excellent career development opportunity, with exposure to all aspects of R&D in the company

 Do you have the right qualifications, a bright mind, sharp instincts, collaborative spirit, and innovative vision and are you interested in joining our entrepreneurial team? Then forward a short motivation letter and your CV to

Job application