Upstream Lead



Chemin du Forriest 1 Eigenbrakel Belgium

Function type



To strengthen our newly formed Global Biologics Manufacturing Sciences & Technology (MSAT) team in Braine-l’Alleud, Belgium, we are looking for a talented individual to fill the position of: Upstream Lead.

As an Upstream Lead you will head the Upstream activities in the MSAT lab and report to the Head of Global Biologics MSAT. You will be responsible for delivering on all lab-based Upstream MSAT activities by managing a team of bench-level scientists and technicians.

More specifically, you will contribute by:

  • Supporting the design and setup of the MSAT lab in our brand-new biotech manufacturing plant.

  • Leading the Upstream activities in the MSAT lab.

  • Acquiring and maintaining process expertise for late-stage and commercial products.

  • Transferring and maintaining small scale models from Development.

  • Providing scientific leadership and ensuring USP lab support for Technology Transfers, Manufacturing operations and deviations / investigations as required, by designing and executing appropriate studies.

  • Leading process optimization studies in support of LCM activities.

  • Supporting Continuous Process Verification (CPV) activities.

  • Supporting Regulatory inspections and submissions.

  • Improving the understanding, robustness and economics of commercial manufacturing processes.

  • Ensuring accurate and complete documentation of any scientific experimental plan, data and report.

  • Authoring and reviewing technical protocols and reports.

  • Leading, mentoring and developing direct reports.

  • Ensuring that MSAT policies, Standard Operating Procedures and Work Instructions are developed and kept up to date.

  • Ensuring that the MSAT lab USP team members are appropriately trained in lab and HSE procedures.

  • Ensuring that the appropriate standards of quality, housekeeping and safety are being applied within the MSAT lab.

  • Building and maintaining good working relationships with stakeholders (Development, Manufacturing, QA, …).

  • Establishing and maintaining familiarity with contemporary industrial standards, practices, technologies, literature and ways of performing lab studies.


Interested? For this position you’ll need the following education, experience and skills:

  • Master’s Degree in a relevant scientific discipline required, PhD preferred.

  • At least 3 years of relevant experience in pharmaceutical industry.

  • Demonstrated Upstream subject matter expertise and hands-on Upstream laboratory experience.

  • Proven scientific leadership, from design of experiment through data analysis and reporting

  • Good understanding of biopharma operations and cGMP are an asset.

  • Experience in Technology Transfer and scale-up / scale-down of drug substance processes is a plus.

  • Proven people and project management skills.

  • Strong communication skills.

  • Ability to communicate effectively and connect with peers from different functions (matrix organization) to ensure projects are delivered.

  • Excellent analytical thinking and problem-solving skills.

  • Very good technical writing skills.

  • Ability to manage multiple tasks and meet deadlines with a high tolerance for ambiguity.

  • Self-motivated, innovation mindset, initiative taker, can-do attitude, team player.

  • Very good knowledge of English, both oral and written, knowledge of French is a plus.


Why you should apply

At UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.

If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.

Job application