Developer of a multi-omics liquid biopsy platform to advance precision cancer medicine (ref. BAP-2024-230)





About the team: The laboratory of Prof. Vermeesch translates and implements novel precision technologies to improve patient care. We use liquid biopsies as a biomarker to monitor and provide early detection of genic and non-genic diseases. Wouter Bossuyt is manager of the genomics core facility and develops NGS technology.

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Project background: 

Genomic medicine moves healthcare from being reactive to disease to being predictive to disease onset or from cure to prevention. Next-generation sequencing technologies have leveraged novel concepts to diagnose, treat and monitor diseases. Analysis of free-floating cfDNA from blood or other body fluids - called “liquid biopsy” -represents an emerging tool that enables non-invasive monitoring of tissue dynamics in multiple human physiological and pathological conditions, including pregnancy, cancer and other conditions. In the ONCNGS project we are developing innovative approaches for (epi)genome-wide cfDNA analysis that can lead to novel applications to monitor cancer. In this project you will help build novel pipelines and perform clinical validation studies demonstrating the value of the new approaches.

The position: 

A bio-IT/Software engineer position to advance the development of a multi-omics liquid biopsy platform. You will be integrated in a development team and work towards productization and commercialization.  We envision this 2 year academic position to evolve into a long term commercial position.

You will: 

• Define testing requirements and acceptance criteria for system integration tracks. 

• Ensure the data quality of the migrated data for all requirements (functional and technical).

• Take responsibility for the creation of the data migration designs and architecture.

• You support the development of the test strategy and provide input for the test scenarios; you test the delivered functionalities. 

• You are in direct contact with the end-users and translate their requirements into functional design.

• You monitor the fit between solution and needs and the implementation of the functional design.


You ideally have: 

• Strong computational, programming and/or data analysis skills with an IT, BioIT or engineering background.

• Experience with data application platforms and visualization tools such as DASH Plotly or Shiny.

• Experience in designing, testing, and deploying data integration.

• Experience with data design, architecture, querying, and data modeling.

• Understanding of XML/JSON syntaxes

• Good Knowledge in several of the following programming languages: Python, R, bash.

• Experience with software development tools such as Visual Studio Code.

• Ideally worked in cloud-based systems before, preferably GCP.

• Project management skills: able to coordinate multiple work streams simultaneously to meet project deadlines.


Working with us: 

We have onsite access to state-of-the-art facilities, including single cell analysis platforms, Flow cytometry, High-Throughput Sequencing,  Bioinformatics, Imaging, high-capacity computing and others. You will be embedded in the KULeuven Genomics Core facility (, the largest sequencing facility in Belgium, which offers a broad portfolio of NGS techniques for academic labs, companies, and hospitals. 

Located in Leuven, a small but vibrant and international town by the river Dijle where centuries of history meet cutting-edge science,  we are only a stone’s throw away from the cosmopolitan city of Brussels, the heart of Europe. 

We are part of the University of Leuven, one of the oldest and most prestigious universities of Europe. Founded in 1425, it is Belgium’s largest university, currently featuring among the best universities in the world according to  the Times Higher Education and recently ranked as Europe’s most innovative for the third year in a row.


For more information please contact Prof. dr. Joris Vermeesch, mail:

KU Leuven strives for an inclusive, respectful and socially safe environment. We embrace diversity among individuals and groups as an asset. Open dialogue and differences in perspective are essential for an ambitious research and educational environment. In our commitment to equal opportunity, we recognize the consequences of historical inequalities. We do not accept any form of discrimination based on, but not limited to, gender identity and expression, sexual orientation, age, ethnic or national background, skin colour, religious and philosophical diversity, neurodivergence, employment disability, health, or socioeconomic status. For questions about accessibility or support offered, we are happy to assist you at this email address.

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