Scientist, Downstream – mRNA Drug Substance





The Cell and Viral Drug Substance team within the GSK Vaccine’s Technical Research and Development organization, has as a mission to develop the next-generation mRNA vaccine platforms for rapid development of new vaccine candidates.

We are looking for a motivated downstream scientist to join the mRNA drug substance Development Unit and be part of the integration of an external partner Drug Substance platform process for clinical & commercial manufacturing of mRNA. Located in Rixensart, Belgium, the position will play a significant role in shaping current and next-generation GSK’s leading mRNA vaccine platforms to accelerate addressing unmet medical needs, an exciting field having a direct impact into patients and global health. This role provides the opportunity to integrate a diverse group of top talented experts in vaccines’ industry, lead key activities and further grow and progress in your career.

Your responsibilities:

  • Internalization of a pre-established downstream mRNA vaccine platform from an external partner and mature its robustness, scalability, and characterization for late-phase CMC development and commercial manufacturing

  • Key contributor to designing, driving and executing hands-on the generation of stage-appropriate data and documentation packages for regulatory submissions using QbD principles (Technical risk assessments, process characterization, etc)

  • Hands-on development work as required according to platform evolution

  • Contribute to building the mRNA platform documentation and workflows, and integration within the upstream, analytical and other transversal teams within the global platform

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • PhD in bio-engineering, biochemistry, biotechnology, chemistry or equivalent or a Master in bio-engineering, biochemistry, biotechnology, chemistry or equivalent.

  • A minimum of 3-5 years’ experience in chromatography and different purification techniques such as tangential flow filtration (TFF) and associated instrumentation such as AKTA chromatography systems and Unicorn software.

  • Two or more years of experience in research and development in Biopharmaceutical industry or government laboratory setting is a must.

  • Excel at complex problem solving through critical thinking using knowledge gained through formal education, experience, and sound judgment.

  • Experience with preparative scale HPLC

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Experience with Quality by Design and development of downstream process for purification large biomolecules, specifically large size mRNA.

  • Experience in Design of Experiments (DoE) & high-throughput process development (e.g. plates or robocolumns in Liquid Handling systems such TECAN)

  • Experience and understanding of nucleic acid analytical technologies.

If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

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